Pearse Wyse (2 March 1928 – 28 April 2009) was an Irish Fianna Fáil and Progressive Democrats politician.
He was born in Cork in 1928. He first held political office in 1960 when he was elected to Cork City Council. Five years later he was first elected to Dáil Éireann as a Fianna Fáil Teachta Dála (TD) and running mate of Jack Lynch at the 1965 general election for the Cork Borough constituency. He was re-elected for various Cork constituencies until he retired from national politics at the 1992 general election.
Wyse was appointed Parliamentary Secretary to the Minister for Finance in 1977 and served as Minister of State at the Department of Finance from 1978 until 1979. A staunch supporter of Jack Lynch, Wyse opposed Charles Haughey in every leadership contest from when he assumed the role, becoming a member of the so-called Gang of 22. He was an associate of Desmond O'Malley and had supported George Colley in the 1979 Fianna Fáil leadership election. Disaffected from the party leadership, Wyse was one of the founders of the Progressive Democrats in 1985. He held his seat as a Progressive Democrats TD at the 1987 and 1989 general elections.
Wyse's seat was retained by Pat Cox at the 1992 general election. He remained a member of Cork City Council until he retired in 1999 having held his seat for almost forty years. He also served as Lord Mayor of Cork in 1967 and 1974.
Wyse died on 28 April 2009 in Cork, aged 81.