William Desmond (died 5 September 1941) was an Irish Cumann na nGaedheal and Fine Gael party politician.
A hotel proprietor, Desmond was first elected to the 7th Dáil in the 1932 general election for the Cork Borough constituency, where his party colleague W. T. Cosgrave (the President of the Executive Council) topped the poll.
He was re-elected at the 1933 election, but lost his seat at the 1937 general election, when the constituency was reduced from a 5-seater to a 4-seater. He then retired from politics.
William Desmond was Lord Mayor of Cork for the term from 1940 to 1941.